Ultimately, the decision of which player to start is largely determined by the composition of your roster (as well as your league's settings).
As an example, Andy Dalton is listed below as a "start" for Week 6. And I'd feel very comfortable going into Week 6 with him as my starting quarterback.
That said, he may be a sit for your team.
In other words, if you owned both Aaron Rodgers and Dalton, you should start Rodgers -- and in turn, bench Dalton.
So while you won't find absolute start-sit recommendations below (use my fantasy football rankings for that instead), the goal here is to highlight some players that I like (and would feel comfortable starting) as well as some players that I dislike for this week (and would prefer to keep on my bench).
With that said, here are some players to potentially start in Week 6:
QB - Andy Dalton, Cincinnati Bengals (at BUF)
Quick question: Which quarterback leads the position in fantasy points scored this season?
Of course, it's Dalton; why else would I ask the question here?! Although Tom Brady has averaged more fantasy points per game, no quarterback has scored more (total) fantasy points through five weeks than Dalton. Perhaps even more impressively, Dalton has finished as a top-11 fantasy quarterback in all five starts this year.
Dalton has three consecutive 300-yard games and has thrown multiple touchdowns in four of five games this season. On the year, he is averaging 303.6 passing yards per game with 13 total touchdowns -- 11 passing and two rushing -- and only two interceptions.
Meanwhile, the Bills have allowed the 10th-most fantasy points to opposing quarterbacks this season. Although they prevented rookie Marcus Mariota from throwing a touchdown last week, they had allowed multiple touchdown passes in each of their first four games.
QB - Blake Bortles, Jacksonville Jaguars (vs. HOU)
Like Dalton, Bortles is off to a great start. The second-year quarterback has scored the sixth-most fantasy points and has three top-10 performances over the past four weeks. During that four-game span, Bortles has thrown nine touchdowns with just two interceptions while scoring a minimum of 16.38 fantasy points in each game.
One of the more athletic quarterbacks in the league, his rushing numbers help to boost his floor. With 112 rushing yards (8.0 yards per carry) this season, Bortles has rushed for 531 yards in his 19 career starts. Only three quarterbacks have more rushing yards since last season.
In a favorable matchup against the Texans, who have allowed the sixth-most fantasy points to opposing quarterbacks, Bortles has a good chance to post another top-12 weekly finish.
RB - DeMarco Murray, Philadelphia Eagles (vs. NYG)
It's been a difficult start to the season for last year's rushing champion. The Eagles offense is starting to turn it around, however, and they are projected to score the fourth-most points (27.0) this week based on Vegas odds.
And not only did the Eagles make some changes to their offense last week, but only four running backs had more touches in Week 5 than Murray (27). Murray parlayed those 27 touches into 120 scrimmage yards and a touchdown.
Granted it was with the Cowboys, but Murray rushed for more than 120 yards in both of his matchups against the Giants last season.
RB - Giovani Bernard, Buffalo Bills (at BUF)
For a fourth consecutive week, Bernard had more touches than teammate Jeremy Hill. Bernard turned his 20 touches including five receptions into 101 yards from scrimmage while Hill had just 25 yards on nine touches. On the season, Bernard is averaging 17.2 touches and 94.6 scrimmage yards per game.
The matchup in Week 6 (Bills) is as difficult as Week 5's matchup (Seahawks), but I'd expect Bernard to once again at least lead Hill in touches and production. Bernard is my 17th-ranked fantasy running back for the week.
RB - Charcandrick West, Kansas City Chiefs (at MIN)
With the season-ending injury to Jamaal Charles, West emerges as the team's top fantasy running back and Andy Reid has compared West to Charles in terms of how he plays. I doubt that he gets the goal-line carries, which could limit his upside, but he should get at least 15 touches, if not more, and is a low-end RB2 in my Week 6 rankings.
RB - LeGarrette Blount, New England Patriots (at IND)
In his last two games against the Colts, both playoff appearances, Blount has 54 carries for 314 yards and seven touchdowns. Yes, SEVEN TDs! Even though I have Dion Lewis ranked higher than Blount, it wouldn't surprise me if Blount finished the week as the top-scoring fantasy running back. He at least has that type of upside based on his past success and usage rate in this matchup.
WR - Brandon Marshall, New York Jets (vs. WAS)
Marshall is an obvious start this week, and every week, but I highlight him here since he's a top-five receiver in my rankings this week. To begin his tenure with the Jets, Marshall has a minimum of 12 fantasy points in all four of his games and carries a three-game streak with 100-plus yards into his Week 6 matchup. With 30/400/3 through four games, Marshall is on pace for 120 catches, 1,600 yards and 12 touchdowns. Averaging 11 targets per game, few receivers are as safe as Marshall, who also possesses a high ceiling in a favorable matchup in Week 6.
WR - Anquan Boldin, San Francisco 49ers (vs. BAL)
After back-to-back disappointing performances, Boldin posted an 8/107/1 line, which was his best game of the season, by far. Often we see players have strong performances against their former teams (a la Andre Johnson in Week 5), but this is a favorable matchup for Boldin. The Ravens have allowed the second-most fantasy points to opposing receivers this season and they have allowed four 100-yard games to opposing pass-catchers this season.
WR - Jarvis Landry, Miami Dolphins (at TEN)
Better in PPR formats, Landry is still a start in standard-scoring formats as well. Landry has double-digit targets in all four of his games this season and has a total of 28 catches for 270 yards. In addition, he has 48 rushing yards and a return touchdown.
The Titans rank first in pass defense (167 yards per game allowed), but no team has faced fewer pass attempts (96) than Tennessee. In fact, their 7.9 pass yards allowed per attempt ranks near the bottom of the league. Only New Orleans, San Francisco and Detroit have allowed more than 7.9 Y/A.
And while the Titans are middle of the pack in terms of fantasy points allowed to receivers, no team has allowed more fantasy points per touch to opposing receivers than the Titans (2.64) this season.
WR - Allen Hurns, Jacksonville Jaguars (vs. HOU)
With exactly 116 yards and a touchdown in consecutive games, Hurns has finished as a top-five fantasy wide receiver in back-to-back weeks. That said, he has been consistent all season. Not only has he scored in three consecutive games, but he has a minimum of 60 yards in all five games this season. Only Julio Jones and Emmanuel Sanders have as many 60-yard games as Hurns this season (but Jones has played six games already).
Even if he drops to third in line for targets behind Allen Robinson and now Julius Thomas, Hurns is still a top-24 fantasy receiver for Week 6.
TE - Gary Barnidge, Cleveland Browns (vs. DEN)
Last week, I put Barnidge on the "sit'em" side of this post and that was a mistake. In his past three games, Barnidge has 20 catches for 319 yards and three touchdowns with a minimum of 6/75/1 in each of those games.
Not only has Barnidge finished as a top-three fantasy tight end for three consecutive games, only Rob Gronkowski and Tyler Eifert have more fantasy points at the position this season. The matchup isn't great, but if you own Barnidge, he should be in your starting lineup.
TE - Richard Rodgers, Green Bay Packers (vs. SD)
In his past two games, Rodgers has a minimum of five catches and 45 yards each week with a total of 14 targets in those two games. Not only does he have the 12th-most fantasy points on the season, but he has a top-10 matchup this week against the Chargers.
Here are some players to potentially sit in Week 6:
QB - Cam Newton, Carolina Panthers (at SEA)
Newton is off to a great start this season; only Brady (25.97/G), Dalton (23.24) and Rodgers (22.41) have scored more fantasy points per game than Newton (21.47) this season. Newton has thrown multiple touchdowns in three consecutive games and he has rushed for 195 yards and two scores in four games this season.
That said, the Seahawks have not allowed a top-20 fantasy quarterback in eight consecutive home games. During that span, they have allowed an average of 141.25 passing yards per game and a total of four passing touchdowns.
Newton was one of those eight starts and he threw for only 171 yards with no touchdowns and one interception last year. In addition, he gained just 24 yards on his 12 rush attempts. As well as he's been playing, there are 12 quarterbacks with a more favorable outlook than Newton this week.
QB - Matthew Stafford, Detroit Lions (vs. CHI)
Although the Bears have limited opposing quarterbacks to less than 200 passing yards in four of five games and have a top-five pass defense in terms of yards allowed, they have also allowed 11 passing touchdowns this season. Only the Buccaneers and Chiefs have allowed more.
Their low passing YPG numbers are at least partly attributable to the fact that they rank second-to-last in scoring differential (-11.2/G) this season as they also rank second in fewest opponent pass attempts per game (28.2/G).
The matchup is certainly more favorable than the numbers may initially suggest, but it's hard to have a lot of faith in Stafford given his difficult start to the season. Stafford has yet to finish as a top-15 weekly fantasy quarterback and has thrown more interceptions (six) than touchdowns (eight). In fact, he was pulled during his three-interception performance last week although he remains the team's starter going forward.
RB - Jonathan Stewart, Carolina Panthers (at SEA)
Although his workload has declined each week, Stewart is still averaging 16.0 touches per game, but he has yet to finish better than the weekly RB28 this season. Stewart is averaging 60.5 YFS per game and has yet to score a touchdown this season. In a difficult matchup where the Panthers are projected by Vegas to score the fewest points (17.0) this week, it's difficult to trust Stewart especially given that Newton is always a threat to vulture the few goal-line opportunities the team may get.
RB - Ameer Abdullah, Detroit Lions (vs. CHI)
Abdullah looked great in the preseason and Week 1 and I like his long-term fantasy outlook. While the Lions have faced some talented run defenses over the past four weeks, Abdullah has just 82 rushing yards on 33 carries (2.48 YPC) and just 32.5 YFS/G over that stretch. Given his ball-security and the team's offensive line struggles plus the fact that Joique Bell should be back this week, Abdullah isn't much more than a flex play for me this week.
RB - Alfred Morris, Washington Redskins (at NYJ)
Through five games, Morris has 25, 18, six, 17 and eight carries, respectively. How many will he get in Week 6? Who knows? Morris has averaged just 3.73 YPC this season and the matchup isn't a good one so Alf could need a large workload to be successful this week. The Jets are one of four teams to have allowed just one rushing touchdown this season and are giving up only 3.8 YPC. And only the Panthers are projected to score fewer points this week based on Vegas odds.
RB - Isaiah Crowell, Cleveland Browns (vs. DEN)
Crowell has finished as a top-20 fantasy running back in three of his past four games including back-to-back weeks, but he has yet to exceed 15 touches in any game this season as he and Duke Johnson are essentially in a timeshare. With the Broncos holding opponents to just 3.3 YPC (second-lowest in the NFL), the matchup doesn't set up favorably for Crowell, who is outside of my top-24 fantasy running backs for the week.
WR - Torrey Smith, San Francisco 49ers (vs. BAL)
As bad as the Ravens pass defense has been, it's still hard to have confidence in two 49ers receivers finishing as a top-24 fantasy receiver. Smith is a high-upside (but high-risk) fantasy receiver in Week 6 (and every week). In five games this season, Smith has finished as a top-10 receiver once and outside the top-50 receivers in his other four games.
While I'd prefer to keep him on my bench in season-long formats, a Colin Kaepernick-Torrey Smith stack is certainly worth a flier as a tournament gamble in daily fantasy contests this week.
WR - Pierre Garcon, Washington Redskins (at NYJ)
Even if DeSean Jackson (questionable) doesn't return this week, Garcon is unlikely to produce WR2-type numbers in Week 6 in a difficult matchup against the Jets. As noted above, the only offense projected to score fewer points is Carolina's and few teams have a secondary as talented as New York's. And even though Garcon has more than 50 yards in four of five games this season, he has finished as a top-30 fantasy wide receiver only once.
WR - Sammy Watkins, Buffalo Bills (vs. CIN)
In typical diva wide receiver fashion, Watkins has publicly whined about not getting the ball and says that he should get 10-plus targets per game. I agree that Watkins is under-utilized (even if whining publicly is never a good idea), but the team's run-first offense (27.6 pass attempts per game) means Watkins will never get double-digit targets on a consistent basis. Perhaps there is a squeaky-wheel effect this week, but Watkins has been battling a calf injury and the team is potentially looking at a quarterback downgrade with Tyrod Taylor being a game-time call this week as well.
WR - Andre Johnson, Indianapolis Colts (vs. NE)
Johnson finished as the weekly WR1 in Week 5 with six catches for 77 yards and two touchdowns against his former team. Before last week, however, Johnson had a total of seven catches for 51 yards on 20 targets with back-to-back goose eggs. At best, Johnson is the third-best fantasy receiver on his own team behind T.Y. Hilton and Donte Moncrief and I'd like to see some consistent production before trusting last week's performance as being anything more than an exception to the rule.
TE - Owen Daniels, Denver Broncos (at CLE)
Targeted five times against the Raiders, who have allowed the most fantasy points to the position, Daniels had zero receptions for zero yards and zero fantasy points. While he had scored in both of his previous two games, Daniels has just 61 yards (5.08 Y/R) through five games.
TE - Heath Miller, Pittsburgh Steelers (vs. ARI)
Until Ben Roethlisberger returns from his knee injury, Miller should remain on your bench. Since Week 1 (8/84 on 11 targets), Miller has 2/15, 2/17, 1/1 and 3/46 in his past four games, respectively. In addition, the Cardinals have allowed the fourth-fewest fantasy points to opposing tight ends this season.
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