San Francisco 49ers 2025 Fantasy Football Projections
Updated: Sunday, August 31, 2025Our 2025 fantasy football projections below are for the San Francisco 49ers.
Projected fantasy points are based on half-PPR scoring.
MORE: Fantasy football projections for more NFL teams
Embed from Getty ImagesQUARTERBACKS
| Player | Att. | Comp. | Yards | TD | INT | Rush | Yards | TD | Points |
|---|---|---|---|---|---|---|---|---|---|
| Brock Purdy | 499.1 | 335.4 | 4042.7 | 27.7 | 12.48 | 61.6 | 246.4 | 3.85 | 295.29 |
| Mac Jones | 37.6 | 24.8 | 267 | 1.47 | 1.05 | 9.5 | 30.4 | 0.19 | 18.64 |
| QB Totals | 536.7 | 360.2 | 4309.7 | 29.17 | 13.53 | 71.1 | 276.8 | 4.04 | 313.93 |
Brock Purdy: Purdy had a down year in 2024 but still finished as the QB10 on a points-per-game basis (18.6). Compared to career rates (in parenthesis), Purdy's 65.9% completion rate (67.5%), 4.4 TD% (6.0%), and 8.5 Y/A (8.9) were all lower in 2024. Yes, Deebo Samuel now plays for the Washington Commanders and Brandon Aiyuk, Jauan Jennings and nearly every other top receiver not named Ricky Pearsall seem to have injury designations (or a suspension), but Purdy is a value when comparing my projections/rankings to his current ADP.
RUNNING BACKS
| Player | Att. | Yards | TD | Rec. | Yards | TD | Points |
|---|---|---|---|---|---|---|---|
| Christian McCaffrey | 236.9 | 1101.6 | 8.88 | 65.7 | 554.8 | 3.7 | 273.97 |
| Brian Robinson Jr. | 87.7 | 372.7 | 2.41 | 10.4 | 82.6 | 0.8 | 69.99 |
| Isaac Guerendo | 62.8 | 285.7 | 2.51 | 6.5 | 58.5 | 0.2 | 53.93 |
| Kyle Juszczyk | 3.6 | 12.6 | 0.29 | 8.5 | 80.7 | 0.6 | 18.92 |
| Jordan James | 2.4 | 10.6 | 0.07 | 1 | 7.2 | 0 | 2.7 |
| RB Totals | 393.4 | 1783.2 | 14.16 | 92.1 | 783.8 | 5.3 | 419.51 |
Christian McCaffrey: Could McCaffrey finish as the RB1 in fantasy in 2025? Sure, as long as his health cooperates. CMC turned 29 earlier this summer and injuries have derailed three of his past five seasons. In those three seasons, he had six different stints of five-plus missed games. Through 31 games with the 49ers, he has racked up 3,581 yards from scrimmage and 31 touchdowns. And so far, so good, heading into 2025 as The Athletic's Matt Marrows notes that if McCaffrey "not back to his 2023 form, he's pretty close to it."
Brian Robinson Jr.: Since being drafted in the third round of the 2022 NFL Draft by the Washington Commanders, Robinson's workload has been consistent — 207-214 touches every year with a career average of 15.49 per game. His per-game fantasy finishes were solid — RB27 (2024), RB21 (2023) and RB35 (2022), respectively. Traded to the 49ers on August 22nd, it will now require an injury to Christian McCaffrey for him to have any fantasy relevance.
Isaac Guerendo: Injuries to Christian McCaffrey and Jordan Mason (now in Minnesota) catapulted Guerendo into a starter's role down the stretch. The speedster (4.33 40-yard dash) finished his rookie campaign with averages of 5.0 yards per carry and 10.1 yards per reception on his 99 touches. CMC is fully healthy now and the team has traded for Brian Robinson Jr., so he's likely multiple injuries away (to CMC and Robinson) from becoming a starting option in fantasy.
WIDE RECEIVERS
| Player | Rec. | Yards | TD | Rush | Yards | TD | Points |
|---|---|---|---|---|---|---|---|
| Ricky Pearsall | 69.4 | 903.8 | 6.8 | 7.1 | 56.8 | 0.36 | 173.72 |
| Jauan Jennings | 65 | 830.6 | 5.6 | 0 | 0 | 0 | 149.16 |
| Brandon Aiyuk | 35.6 | 512.4 | 3.1 | 0 | 0 | 0 | 87.64 |
| Demarcus Robinson | 12.9 | 163.8 | 1.4 | 0 | 0 | 0 | 31.23 |
| Jacob Cowing | 3.4 | 43.8 | 0.2 | 2.4 | 14.4 | 0.12 | 9.44 |
| Jordan Watkins | 1.6 | 20.5 | 0.1 | 0 | 0 | 0 | 3.45 |
| Russell Gage | 0.8 | 8.6 | 0 | 0 | 0 | 0 | 1.26 |
| Skyy Moore | 0.7 | 8.5 | 0 | 0 | 0 | 0 | 1.2 |
| WR Totals | 189.4 | 2492 | 17.2 | 9.5 | 71.2 | 0.48 | 457.1 |
Ricky Pearsall: Shot in the chest the week before the season, Pearsall's rookie campaign was as atypical as they come, but optimism for a breakout abounds heading into his second season. The former first-round pick closed 2024 strong (14/210/2 in final two games), the wide receiver corps has been depleted by injuries, and the scheme and play calling will put him in position to capitalize.
Jauan Jennings: Jennings had a breakout season in 2024 with 77 catches for 975 yards and six touchdowns on a team-high 113 targets. With Deebo Samuel Sr. in Washington and Brandon Aiyuk likely to miss the start of the season, Jennings has the opportunity to build upon last year's success (especially early in the season). That said, GM John Lynch has said that the 49ers are "hopeful but not sure on Week 1" when it comes to Jennings' availability.
Brandon Aiyuk: It's unclear when Aiyuk (knee) will return, but Kyle Shanahan said it could be Week 6 as a "rough estimate." And then how long will it take for him to get back to (his) normal?
TIGHT ENDS
| Player | Rec. | Yards | TD | Rush | Yards | TD | Points |
|---|---|---|---|---|---|---|---|
| George Kittle | 72.6 | 981.3 | 6.3 | 0 | 0 | 0 | 172.23 |
| Luke Farrell | 5.9 | 52.7 | 0.2 | 0 | 0 | 0 | 9.42 |
| TE Totals | 78.5 | 1034 | 6.5 | 0 | 0 | 0 | 181.65 |
George Kittle: Kittle finished 2024 with 78 receptions for 1,106 yards and eight touchdowns, all of which rank either second or third in his career. Injuries to Brandon Aiyuk and Christian McCaffrey led to greater consistency from Kittle — 40-plus receiving yards in 13 of 15 games played. Only Bowers had more (14 of 17 games). While Kittle always finishes the year with excellent overall numbers, previous seasons featured more boom-or-bust weeks. For example, his number of 40-yard games were considerably lower in previous seasons — 10 in 2023, six in 2022, and eight in 2021. Among tight ends, Kittle has either led or shared in the lead in PFF's yards per route run metric in all but one season (2022) from 2018 to 2024.