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They're well-coached and still have some talented players, so the 49ers could be frisky in the weeks ahead. But for all intents and purposes, their season is over, given the injury news on Jimmy Garoppolo and George Kittle. And it's fair to wonder how committed the 49ers will be to Garoppolo going forward. Garoppolo has no guaranteed money remaining on his contract. Whether San Francisco wants to make a move at quarterback could be one of the most interesting aspects of the 2021 offseason.

They couldn't get much of anything going on offense against the Seahawks until it was too late. Now they have to play without Jimmy Garoppolo and George Kittle. When do the injuries end?

It may seem like virtually all of their key players are sidelined, but San Francisco has time to heal given it plays once in 24 days following this week's Thursday night date with Green Bay.

Reason for optimism: Coaching and rest

The biggest point of optimism for the Niners should be that they're bound to have better injury luck at some point, but based on how it's going, that can't be counted on. What can be is a coaching staff that has found ways to cover up for many of the warts that the injuries have exposed. That's not always the case, as Sunday's ugly loss to Seattle would attest, but it's been enough to keep the Niners in the mix. They also will get a mini-bye after a Thursday night game this week, and their actual bye is just a few weeks off. That rest is much-needed as the Niners eagerly await reinforcements. -- Nick Wagoner

A devastating Sunday for the manic 49ers, who were blown out by the rival Seahawks and lost both Jimmy Garoppolo and George Kittle to injuries. Garoppolo suffered a high ankle sprain and Kittle has a small fracture in his foot -- both stars are expected to miss multiple weeks. A hobbled Garoppolo was off his game before exiting on Sunday, unable to move the ball consistently against an undermanned Seattle defense that entered action allowing close to 500 yards per game. A short week is a worst-case scenario for San Francisco, which will not be close to full strength for a difficult Thursday Night Football matchup against the Packers.