Historical Won-Loss Records (Head to Head): San Francisco 49ers
The table below shows San Francisco 49ers results head-to-head versus other NFL franchises.
More: San Francisco 49ers Year-by-Year Records
More: NFL Playoffs: Active Playoff Streaks and Droughts
| REGULAR SEASON | PLAYOFFS | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Opponent | G | W-L-T | W-L% | PF | PA | W-L-T | W-L% | PF | PA |
| Arizona Cardinals | 69 | 38-31-0 | 0.551 | 1628 | 1434 | 0-0-0 | |||
| Atlanta Falcons | 81 | 48-32-1 | 0.599 | 1921 | 1438 | 1-1-0 | 0.500 | 46 | 44 |
| Baltimore Ravens | 7 | 2-5-0 | 0.286 | 118 | 162 | 0-1-0 | 0.000 | 31 | 34 |
| Buffalo Bills | 14 | 6-8-0 | 0.429 | 303 | 303 | 0-0-0 | |||
| Carolina Panthers | 23 | 10-13-0 | 0.435 | 534 | 554 | 1-0-0 | 1.000 | 23 | 10 |
| Chicago Bears | 68 | 34-33-1 | 0.507 | 1518 | 1395 | 3-0-0 | 1.000 | 95 | 18 |
| Cincinnati Bengals | 16 | 11-5-0 | 0.688 | 370 | 326 | 2-0-0 | 1.000 | 46 | 37 |
| Cleveland Browns | 30 | 11-19-0 | 0.367 | 583 | 604 | 0-1-0 | 0.000 | 7 | 21 |
| Dallas Cowboys | 32 | 17-14-1 | 0.547 | 856 | 756 | 4-5-0 | 0.444 | 190 | 213 |
| Denver Broncos | 15 | 7-8-0 | 0.467 | 329 | 347 | 1-0-0 | 1.000 | 55 | 10 |
| Detroit Lions | 67 | 38-28-1 | 0.575 | 1500 | 1434 | 2-1-0 | 0.667 | 85 | 85 |
| Green Bay Packers | 64 | 28-35-1 | 0.445 | 1325 | 1353 | 6-4-0 | 0.600 | 228 | 239 |
| Houston Texans | 6 | 4-2-0 | 0.667 | 139 | 93 | 0-0-0 | |||
| Indianapolis Colts | 46 | 19-27-0 | 0.413 | 932 | 1100 | 0-0-0 | |||
| Jacksonville Jaguars | 8 | 5-3-0 | 0.625 | 203 | 136 | 0-0-0 | |||
| Kansas City Chiefs | 15 | 7-8-0 | 0.467 | 286 | 346 | 0-2-0 | 0.000 | 42 | 56 |
| Las Vegas Raiders | 15 | 8-7-0 | 0.533 | 362 | 277 | 0-0-0 | |||
| Los Angeles Chargers | 15 | 7-8-0 | 0.467 | 396 | 339 | 1-0-0 | 1.000 | 49 | 26 |
| Los Angeles Rams | 152 | 78-71-3 | 0.523 | 3434 | 3257 | 1-1-0 | 0.500 | 47 | 23 |
| Miami Dolphins | 15 | 6-9-0 | 0.400 | 325 | 287 | 1-0-0 | 1.000 | 38 | 16 |
| Minnesota Vikings | 45 | 20-24-1 | 0.456 | 1009 | 1000 | 5-1-0 | 0.833 | 181 | 104 |
| New England Patriots | 15 | 10-5-0 | 0.667 | 385 | 281 | 0-0-0 | |||
| New Orleans Saints | 79 | 50-27-2 | 0.646 | 1914 | 1489 | 1-0-0 | 1.000 | 36 | 32 |
| New York Giants | 36 | 19-17-0 | 0.528 | 760 | 712 | 4-4-0 | 0.500 | 178 | 176 |
| New York Jets | 15 | 12-3-0 | 0.800 | 376 | 253 | 0-0-0 | |||
| Philadelphia Eagles | 35 | 20-14-1 | 0.586 | 798 | 804 | 2-1-0 | 0.667 | 44 | 50 |
| Pittsburgh Steelers | 23 | 13-10-0 | 0.565 | 463 | 474 | 0-0-0 | |||
| Seattle Seahawks | 54 | 23-31-0 | 0.426 | 1035 | 1248 | 1-2-0 | 0.333 | 64 | 87 |
| Tampa Bay Buccaneers | 28 | 21-7-0 | 0.750 | 655 | 444 | 0-1-0 | 0.000 | 6 | 31 |
| Tennessee Titans | 16 | 10-6-0 | 0.625 | 375 | 327 | 0-0-0 | |||
| Washington Commanders | 32 | 20-11-1 | 0.641 | 767 | 593 | 3-1-0 | 0.750 | 93 | 67 |
Records updated through 2025 NFL season. Stats via by Pro-Football-Reference.com.